DR. NOBLE TALKS: What you need to know about HRT Have you ever wondered why finding hormone balance feels so complex? Few topics have sparked as much debate over the past 25 years as hormone replacement therapy (HRT) for both men and women. Unfortunately, it’s not as simple as inserting a hormone pellet into the fat over your glutes every 3-4 months. (And honestly, I often wonder what those glutes look like after ten years and thirty pellets!) While there may be a place for this method in select cases, it should NEVER be the first-line approach.